Start with your mattress manufacturer’s care label. For routine upkeep, wash the bedding, vacuum the mattress surface if permitted, and let everything dry completely. For a spill, blot promptly and use only a method the manufacturer approves; saturating foam or padding can cause damage.
How to clean a mattress: step by step
- Read the care instructions. Covers and internal materials vary. Some foam mattresses should not get wet at all; for example, Tempur-Pedic’s product-care instructions distinguish the cover from the mattress material.
- Strip the bed. Wash sheets and the protector according to their labels. Remove a mattress cover only if its instructions say it is removable.
- Vacuum if allowed. Use a clean upholstery attachment on the surface, edges and seams to pick up loose dust and debris. Use a gentle setting and avoid damaging fabric.
- Treat a spill carefully. Blot rather than rub. If the manufacturer permits spot cleaning, test its recommended solution on an inconspicuous area and use as little moisture as possible.
- Dry fully. Allow any treated area and washable cover to dry completely before remaking the bed. A fan and ventilation may help; avoid heat or direct sun if prohibited by the label.
What about stains and odors?
Act quickly and consult the care label first. A stain may remain even after appropriate treatment, and a strong odor can signal moisture or contamination deeper in the mattress. Fragrance sprays can cover a smell without resolving its source. Do not mix cleaning chemicals or assume a DIY recipe is safe for every foam, fabric or finish.

Dust mites and mattress protectors
Vacuuming removes surface debris but cannot guarantee that mites or allergens deep in a mattress have been eliminated. If dust mites are an asthma trigger, the CDC recommends allergen-proof mattress and pillow covers, regular bedding washing and other environmental measures. An ordinary spill protector and a zippered allergen encasement are different products; check what the label claims.

Ben’s experience with a mattress vacuum
In the original article, I described using a Raycop RS2 and being surprised by the amount of debris it collected from mattresses. That observation is useful for surface cleaning, but it does not establish how many mites or microbes were removed, or how far UV light penetrated. Read the original Raycop RS2 review for the device experience.

Cleaning methods to approach cautiously
Heat and moisture can damage some mattresses. Use only if the manufacturer explicitly permits the method.
Do not use ozone as a routine home mattress-cleaning shortcut. The EPA warns that inhaled ozone can harm lungs and aggravate respiratory conditions.
Device claims do not prove a whole mattress is sanitized. Effectiveness depends on exposure and the surface being treated.
They can leave residue or irritate sensitive users; confirm compatibility before applying anything to the mattress.
When cleaning may not be enough
Deep moisture, visible mold, a persistent odor, extensive contamination or structural damage may call for professional assessment or replacement. Cleaning also will not repair collapsed layers or a broken foundation. See our guide to signs it is time to replace a mattress.
Frequently asked questions
Can baking soda eliminate dust mites?
Do not rely on it to eliminate an infestation or allergens. It may help with some odors if the mattress maker permits its use.
How often should I clean a mattress?
Follow its care instructions and address spills promptly. Wash bedding and protectors regularly according to their labels.
Should I steam-clean memory foam?
Only if the mattress manufacturer explicitly allows it. Many foam products are sensitive to moisture and heat.
Does a mattress protector prevent every allergen?
No. A suitable encasement can be one part of an allergen-control plan, but check its specific claims and consult a clinician about persistent symptoms.