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Protect Your Bed: Best Hypoallergenic Mattress Covers of 2024


Finding the best hypoallergenic mattress cover can be a game-changer for anyone battling allergies, dust mites, or bedbugs. Hypoallergenic mattress covers act as a protective barrier, offering both comfort and peace of mind. Designed to trap allergens like dust mites, pet dander, and pollen, these covers significantly improve sleep quality for allergy sufferers.

If you need quick recommendations, here are our top picks for 2024:

  • Best Overall: Luna Hypoallergenic Waterproof Mattress Protector
  • Best Organic Cotton: Whisper Organic Mattress Protector
  • Best Budget-Friendly: Sleep Defense System Waterproof/Bed Bug Proof Mattress Encasement

Without further delay, let’s delve into why these hypoallergenic mattress covers are essential and explore some of the best options available today.

Top Features of Hypoallergenic Mattress Covers - best hypoallergenic mattress cover infographic pillar-3-steps

Why You Need a Hypoallergenic Mattress Cover

Dust Mites and Allergens

Dust mites are tiny creatures that thrive in household dust, feeding on dead skin cells. They can be a major trigger for allergies and asthma. Dr. Neil L. Kao, from the Allergic Disease and Asthma Center, explains that dust mites are nearly impossible to eliminate completely, but a hypoallergenic mattress cover can trap up to 99.95% of these allergens, significantly reducing exposure. This makes a huge difference for those suffering from allergies.


Bedbugs are another concern. They can infest mattresses and cause itchy bites. According to Jeff White, technical director at BedBug Central, a quality mattress cover can act as a barrier, preventing bedbugs from settling in your mattress. Richard Cooper from BedBug Central also highlights that some covers are specifically designed to be bedbug-proof, offering an added layer of protection.

Protection and Comfort

Hypoallergenic mattress covers do more than just protect against allergens and pests. They also keep your mattress clean from sweat, oils, and spills. This is much easier and cheaper than replacing your mattress. Dr. Sujay Kapadia, president of Hospitology Products, notes that a good mattress cover doesn’t alter the feel of your mattress but adds a protective layer that is easy to clean.

Health Benefits

Using a hypoallergenic mattress cover can lead to better sleep quality and overall health. Dr. Andrew S. Kim from the Allergy & Asthma Center of Fairfax emphasizes that reducing exposure to allergens can alleviate symptoms like sneezing, itching, and congestion. This leads to a more restful night’s sleep and improved daytime functioning.

Real-Life Impact

A study published in the Annals of Allergy, Asthma & Immunology found that using allergen-impermeable mattress covers significantly reduced asthma and allergy symptoms in participants. Another study in the New England Journal of Medicine showed similar results for patients with allergic rhinitis.

In summary, a hypoallergenic mattress cover is a simple, effective way to protect your health and improve your comfort. It keeps allergens and pests at bay, protects your mattress, and enhances your sleep quality.

Dust Mites - best hypoallergenic mattress cover

Best Hypoallergenic Mattress Covers of 2024

Protect-A-Bed AllerZip Smooth Mattress Encasement

The Protect-A-Bed AllerZip Smooth Mattress Encasement stands out for its strong seams and superior zipper closure. These features are essential for keeping bedbugs and dust mites out. The smooth fabric ensures comfort and is quiet to sleep on, making it a top choice for those who prioritize both protection and a good night’s sleep. It fits snugly on a 9-inch-deep mattress and comes in various sizes to suit different beds. This encasement is a bit pricier but worth the investment for its durability and effectiveness.

Sleep Defense System Waterproof/Bed Bug Proof Mattress Encasement

For those on a budget, the Sleep Defense System Waterproof/Bed Bug Proof Mattress Encasement by Hospitology is a great option. It features solid seam stitching, a sturdy zipper, and a Velcro closure to keep bedbugs out. While the fabric is thicker and noisier compared to the Protect-A-Bed option, it offers excellent protection at about a third of the price. This makes it a budget-friendly choice without compromising on essential protective features.

Malouf Sleep Tite Encase Omniphase Pillow Protectors

If you’re looking for a premium option, consider the Malouf Sleep Tite Encase Omniphase Pillow Protectors. These pillow covers feature moisture-wicking fabric with a silky feel that is utterly silent. Each cover has a secure zipper, ensuring that no allergens or pests can get through. Though they are more expensive, their comfort and high-quality materials make them a worthwhile investment for those who can afford it.

Tontine SleepTight Anti Allergy Mattress Topper

The Tontine SleepTight Anti Allergy Mattress Topper is made from premium polyester fiber, providing excellent cushioning and comfort. It’s endorsed by the National Asthma Council Australia, which speaks to its effectiveness in reducing allergens. This topper is a great choice if you want to add an extra layer of comfort to your mattress while also protecting against dust mites and other allergens.

Frio Total Encasement Protector

For those who sleep hot, the Frio Total Encasement Protector is an excellent choice. It features cooling technology that keeps you comfortable throughout the night. This protector is also efficient in keeping out dust mites and is hypoallergenic. Its combination of cooling properties and allergen protection makes it a standout option for hot sleepers who need a reliable mattress cover.

These are some of the best hypoallergenic mattress covers of 2024, each offering unique features to suit different needs and budgets. Whether you need something budget-friendly or are willing to splurge on a premium option, there is a mattress cover on this list that will help you sleep better and stay healthier.

What Makes a Mattress Cover Hypoallergenic?

Hypoallergenic mattress covers are designed to keep allergens at bay, ensuring a healthier sleep environment. Here’s what makes a mattress cover truly hypoallergenic:

Fabric Pore Size

The fabric’s pore size is crucial. A tightly woven fabric with a small pore size—typically less than 10 microns—prevents dust mites and their allergens from penetrating the cover. For instance, the BedCare™ All-Cotton Allergy Mattress Covers feature a mean pore size of just 2.6 microns, effectively blocking dust mites and other allergens.

Mold and Bacteria Protection

Hypoallergenic covers also guard against mold and bacteria, which can thrive in warm, moist environments. Materials like latex and copper are naturally resistant to these microbes. According to Forbes, latex foam mattresses are particularly effective in keeping mold and bacteria at bay.

Dust Mite Allergen Barrier

Dust mites feed on dead skin cells and thrive in humid environments. Quality hypoallergenic covers trap these allergens, preventing them from becoming airborne and causing respiratory issues. For example, the SafeRest Premium Hypoallergenic Waterproof Mattress Protector is designed to block dust mites, providing a cleaner sleeping surface.

Breathable Materials

Breathability is another key factor. Materials like cotton and bamboo allow air to circulate, reducing heat buildup and moisture retention, which can lead to mold growth. The Coop Home Goods Premium Bamboo Mattress Protector is a great example, combining bamboo rayon and polyester for a breathable, cool sleep experience.

Polyurethane Layer

Many hypoallergenic mattress covers include a thin polyurethane layer for waterproofing. This layer blocks liquids without trapping heat, unlike vinyl protectors. The SafeRest Mattress Protector uses a polyurethane membrane that is free from vinyl, PVC, and phthalates, ensuring it’s safe and effective.

By understanding these features, you can choose a hypoallergenic mattress cover that best suits your needs, ensuring a healthier and more comfortable sleep environment.

How to Choose the Best Hypoallergenic Mattress Cover

Choosing the best hypoallergenic mattress cover involves considering several key factors: material, fit, comfort, durability, ease of cleaning, and budget.


The material of the mattress cover is crucial. Look for fabrics like organic cotton, bamboo, or polyester blends. These materials are breathable and hypoallergenic. For example, the Whisper Organic Mattress Protector is made from 100% GOTS-certified organic cotton, offering a plush and luxurious feel.

Polyurethane layers are also common, providing waterproofing without the heat-trapping properties of vinyl. The Luna Hypoallergenic Waterproof Mattress Protector combines cotton and polyurethane for effective protection against liquids and allergens.


Ensure the cover fits your mattress snugly. Measure the depth of your mattress and choose a cover that accommodates it. A zippered encasement, like the Protect-A-Bed AllerZip Smooth Mattress Encasement, offers full protection on all sides, sealing out dust mites and bedbugs effectively.


Comfort is non-negotiable. Some covers add a soft layer to your mattress without changing its feel. The Malouf Sleep Tite Encase Omniphase Pillow Protectors are known for their moisture-wicking and silky feel, ensuring a comfortable sleep.


Durability means the cover can withstand repeated use and washing. High-quality materials like cotton or polyester blends tend to last longer. The Sleep Defense System Waterproof/Bed Bug Proof Mattress Encasement features solid seam stitching and a sturdy zipper, ensuring it holds up over time.

Ease of Cleaning

Choose a cover that is easy to remove and machine washable. Covers like the Malouf HD Encasement allow you to zip off the top layer for easy washing without removing the entire cover.


Finally, consider your budget. There are options at various price points. The Tontine SleepTight Anti Allergy Mattress Topper offers premium polyester fiber cushioning and is endorsed by the National Asthma Council Australia, providing great value for its price.

By keeping these factors in mind, you can find a hypoallergenic mattress cover that meets your needs and ensures a healthier, more comfortable sleep environment.

Frequently Asked Questions about Hypoallergenic Mattress Covers

Do anti-allergy mattress protectors work?

Yes, anti-allergy mattress protectors do work. They create a barrier that prevents dust mites, pet dander, and other allergens from penetrating your mattress. According to research, using a zippered mattress encasement that seals the entire mattress on all sides is the most effective. These covers can trap 99.95% of allergens like dust mites, animal dander, and pollen, providing a safer and cleaner sleeping environment.

What is the best material to cover a mattress?

The best material to cover a mattress depends on your specific needs. Common materials include:

  • Cotton: Breathable and comfortable, but not waterproof.
  • Polyurethane: Waterproof and effective against allergens, though it may retain heat.
  • Bamboo: Naturally antibacterial and breathable.
  • Latex: Resistant to mold and dust mites, making it a great hypoallergenic option.

For instance, the Protect-A-Bed AllerZip Smooth Mattress Encasement uses a blend of cotton and polyurethane to balance comfort and protection.

Is there a mattress topper for allergies?

Yes, there are mattress toppers specifically designed to reduce allergen exposure. These toppers are made from hypoallergenic materials like latex, bamboo, or organic cotton. For example, the Tontine SleepTight Anti Allergy Mattress Topper is filled with premium polyester fiber and is endorsed by the National Asthma Council Australia. It provides an additional layer of comfort while protecting against allergens.

By choosing the right hypoallergenic mattress cover or topper, you can significantly improve your sleep quality and reduce allergy symptoms.


Choosing the right hypoallergenic mattress cover is essential for a good night’s sleep, especially if you suffer from allergies. At Yawnder, we understand how important it is to find products that not only protect you from allergens but also enhance your comfort.

Our expert evaluations ensure that we recommend only the best hypoallergenic mattress covers. From dust mite protection to cooling technology, our selections are designed to meet various needs and budgets.

We also offer a range of hypoallergenic mattresses and bedding options that are both comfortable and durable. Whether you need a mattress encasement, pillow protector, or a complete bedding set, you’ll find what you’re looking for at Yawnder.

And the best part? We make it easy for you. With our direct-to-door shipping, you can have your new mattress or bedding delivered right to your home without any hassle.

Don’t settle for anything less than the best. Visit our Natural Mattresses page to explore our top-rated products and start waking up refreshed and allergy-free.

Thank you for trusting Yawnder with your sleep needs. Sweet dreams!

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Text us at 858-232-5760 for assistance. We’re happy to help!

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